Capillary morphogenesis protein 2
WebJan 15, 2024 · 2 Department of Chemistry, Wichita State University, Wichita, Kansas, USA. ... in the presence and absence of the soluble von Willebrand factor A domain of the human form of receptor capillary morphogenesis protein 2 (sCMG2), to elicit antibodies to PA in BALB/c mice. Prior studies showed that sCMG2 stabilizes the 83-kDa PA structure to pH ... WebSep 21, 2024 · Due to mutations in capillary morphogenesis protein 2 (CMG2) gene on chromosome 4q21, which cause retention of CMG2 in endoplasmic reticulum ( Hum Mutat 2009;30:583, Am J Hum Genet 2003;73:791, Am J Hum Genet 2003;73:957 ) Clinical features Progressive, chronic, and often debilitating disease
Capillary morphogenesis protein 2
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WebApr 16, 2003 · However, in this report we identify the human capillary morphogenesis protein 2 (CMG2) as a second anthrax toxin receptor. CMG2 is the protein most similar … WebJul 28, 2009 · Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo Proc Natl Acad Sci U S A. 2009 Jul 28;106 (30):12424-9. doi: …
WebApr 9, 2024 · Capillary Morphogenesis Gene Protein 2 (CMG2) Mediates Matrix Protein Uptake and is Required for Endothelial Cell Chemotaxis in Response to Multiple … WebJan 3, 2024 · Since this activity requires the surface expression of the capillary morphogenesis protein-2 (CMG2) toxin receptor, genetic manipulation of CMG2 …
WebJan 4, 2012 · Capillary morphogenesis gene 2 (CMG2) is a type I membrane protein involved in the homeostasis of the extracellular matrix. While it shares interesting similarities with integrins, its exact molecular role is unknown. The interest and knowledge about CMG2 largely stems from the fact that it is involved in two diseases, one infectious and one ... WebHere, we established mice with CMG2 only expressed in tumor endothelial cells (ECs) and determined the specific contribution of tumor stromal ECs to the toxin’s antitumor activity. Our results demonstrate that disruption of ERK signaling only within tumor ECs is sufficient to halt tumor growth.
WebTwo distinct cellular receptors for anthrax toxin have been identified and are designated capillary morphogenesis protein 2 (CMG2) and anthrax toxin receptor/tumor endothelial marker 8 (ATR/TEM8). The molecular details of the toxin-receptor interactions have been revealed through crystallographic, biochemical and genetic studies.
WebDetects human CMG‑2/ANTXR2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 20% cross-reactivity with recombinant mouse CMG-2 is observed. Source Polyclonal Goat IgG Purification Antigen Affinity-purified Immunogen Mouse myeloma cell line NS0-derived recombinant human CMG‑2/ANTXR2 isoform 1 … michigan lakefront vacation rentalsWebOct 18, 2016 · Infanile systemic hyalinosis (ISH) is caused by mutations in the gene encoding capillary morphogenesis protein-2 ( CMG2, or ANTXR2; 608041) on chromosome 4q21.21 [ 1 – 3 ]. The disorder is allelic with juvenile hyaline fibromatosis, which has milder clinical features. michigan lake shore resortsWebFeb 23, 2024 · Capillary morphogenesis protein 2 (CMG2) was originally identified through its participation in capillary morphogenesis, and subsequently identified as the … michigan lakes real estateWebA complex role of anthrax toxin receptor 2 polymorphisms and capillary morphogenesis protein 2 in ankylosing spondylitis pathogenesis A complex role of anthrax toxin receptor 2 polymorphisms and capillary morphogenesis protein 2 in ankylosing spondylitis pathogenesis doi: 10.1007/s10067-015-3158-9. Epub 2016 Jan 4. Authors michigan lakes and streams associationWebCapillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo Shihui Liu1, Devorah Crown, Sharmina Miller-Randolph, Mahtab Moayeri, … michigan lakes by sizeWebThis condition is due to mutations in the anthrax toxin receptor-2 ( ANTXR2) gene. This gene is also known as capillary morphogenesis protein-2. This gene is located on the long arm of chromosome 4 (4q21.21). Management [ edit] There is no presently known curative treatment for this condition. [citation needed] Management is supportive michigan lake vacation spotsWebJun 27, 2024 · It is hypothesized that disruption of this membrane protein causes accumulation of hyaline materials and tissue damage/malfunction in multiple organs. 7 Owing to its rarity and associated rapid clinical deterioration, timely diagnosis of ISH is difficult and, as a result, it may be underdiagnosed. the novacene