Tīmeklis2024. gada 21. maijs · Reinforcing the critical role of QKI-5 for recruiting and activating SREBP2 on the promoters of cholesterol biosynthesis … TīmeklisQki regulates myelinogenesis through Srebp2-dependent cholesterol biosynthesis eLife May 4, 2024 See publication. Glioma Stem Cells: Signaling, Microenvironment, and Therapy Stem Cells ...
Qki regulates myelinogenesis through Srebp2-dependent …
TīmeklisThe dynamics of droplet impact and splash is important in many applications, yet its analysis involves difficult intertwined aspects. Here Liu et al. make shape parametrically accessible to ... TīmeklisMechanistically, Qki-5 functions as a co-activator of Srebp2 to control transcription of the genes involved in cholesterol biosynthesis in oligodendrocytes. Consequently, Qki depletion led to substantially reduced concentration of cholesterol in mouse brain, impairing proper myelin assembly. Our study demonstrated that Qki-Srebp2 … shockwaves hair gel ebay uk
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Tīmeklis2024. gada 30. janv. · As similarly seen with Pparβ, Qki was recently identified as a co-activator for Srebp2 in OLs. 109 Loss of Qki-dependent co-activation in OLs significantly disrupted Srebp2-mediated transcription of cholesterol biosynthesis pathways, which blunted myelination and caused severe congenital hypomyelination accompanied by … TīmeklisMechanistically, we demonstrate that Qki enhances cholesterol biosynthesis by recruiting Srebp2 and Pol II in the promoter regions of cholesterol biosynthesis genes. Supporting its function as a transcription co-activator, we show that Qki directly interacts with single-stranded DNA. TīmeklisTogether, we propose that Qki-Srebp2–mediated cholesterol biosynthesis is essential for maintaining high demand for cholesterol in lens cells and oligodendrocytes. Our finding potentially provides tissue-specific mechanisms to modulate cholesterol biosynthesis to prevent cataracts and various neurological diseases. Keywords. race cars black